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Why Buy Menthol Crystals? What is Menthol ?
Menthol is an organic compound made synthetically or obtained from corn mint, peppermint, or other mint oils. It is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. Menthol also acts as a weak kappa opioid receptor agonist.
Menthol ability to chemically trigger the cold-sensitive TRPM8 receptors in the skin is responsible for the well-known cooling sensation it provokes when inhaled, eaten, or applied to the skin. In this sense, it is similar to capsaicin, the chemical responsible for the spiciness of hot chilis (which stimulates heat sensors, also without causing an actual change in temperature).
Menthol’s analgesic properties are mediated through a selective activation of κ-opioid receptors. Menthol also blocks voltage-sensitive sodium channels, reducing neural activity that may stimulate muscles. A study showed that topical absorption of ibuprofen is not increased by menthol, but does note the complementary effect of the menthol as a pain reliever itself.
Some studies show that menthol crystal acts as GABAA receptor positive allosteric modulator and increases GABAergic transmission in PAG neurons. Menthol also shares anaesthetic properties similar to propofol, by modulating the same sites of the GABAA receptor.
Menthol crystal is widely used in dental care as a topical antibacterial agent, effective against several types of streptococci and lactobacilli
Natural menthol is obtained by freezing peppermint oil. The resultant crystals of menthol are then separated by filtration. Menthol crystal (dl-menthol) are produced through mint essential oil (mentha arvensis) extraction, the oil is quick frozen and the menthol crystallizes out.
Menthol Legal Status
Menthol is registered as an OTC skin protectant drug with the FDA. This means that if you want to sell a finished product containing menthol and you make a skin protectant claim (incl. insect bites and insect stings), menthol must then be listed under ‘Active Ingredients’ on the label. Also, your facility and your product must be registered with the FDA and you must operate under cGMP guidelines. However, if no skin protectant drug claims are made on the label, menthol is not considered a OTC drug and no registration is needed.