Isopropylphenidate (also known as IPH, IPPH, and IPPD) is synthetic stimulant of the piperidine chemical class that produces stimulating, motivating, and focus enhancing effects when administered. It is a structural analog of the widely-prescribed ADHD medication methylphenidate and is reported to produce near identical cognitive and physical effects, albeit with less of a euphoric “rush” component and a drawn-out duration of action, properties that many find preferable for use as a study-aid or productivity enhancer.
Isopropylphenidate has been investigated for its potential use as a replacement for methylphenidate in the treatment of ADHD and related disorders. One study found that it displayed the same basic activity as a norepinephrine-dopamine reuptake inhibitor (NDRI), possessing, along with both methylphenidate and ethylphenidate, an appreciably high affinity for the dopamine transporter and effects on its cellular reuptake. It displayed comparably minor effects on norepinephrine, however, which was theorized to mean it may possess a more desirable safety and toxicity profile.
Isopropylphenidate has an extremely short history of recreational use in human and has yet to be documented being sold on the streets. It was initially released following the banning of ethylphenidate, which on April 2015 became illegal in the United Kingdom following a temporary-then-permanent blanket ban. Shortly after, it became made available for sale on the online gray market as a research chemical for global distribution.
As of 2017, isopropylphenidate continues to remain available and ambiguously legal in many parts of the world, distributed almost exclusively by online research chemical vendors.
Isopropylphenidate is a synthetic molecule of the substituted phenethylamine and piperidine classes. It contains a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group via an ethyl chain. It is structurally similar to amphetamine, featuring a substitution at Rα which is then incorporated into a piperidine ring ending at the terminal amine of the phenethylamine chain. Additionally, it contains an isopropyl acetate bound to R2 of its molecular structure, a noticeable departure from methylphenidate, which contains a methyl group in this position.
Isopropylphenidate structurally diverges from ethylphenidate and methylphenidate by the length of the carbon chain on their acetate group. Iso- regards the side chain of one carbon atom branching into two bound methyl groups, phen- indicates the phenyl ring, id- is contracted from the piperidine ring, and -ate indicates the acetate group. Isopropylphenidate is a chiral compound, and has been documented as being produced as a racemic mixture and exclusively as either of its enantiomers.