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4-HO-MET is a lesser-known psychedelic drug. 4-HO-MET aslo known as 4-hydroxy-N-methyl-N-ethyltryptamine, or metocin, methylcybin, Colour. 4-HO-MET is a structural and functional analog of psilocin as well as the 4-hydroxyl analog of MET.
4-Hydroxy-N-methyl-N-ethyltryptamine (also known as 4-HO-MET, Methylcybin, Metocin, and “Colour”) is a novel psychedelic substance of the tryptamine class that produces psilocybin-like psychedelic effects when administered. It is structurally related to psychedelic tryptamines like 4-AcO-DMT, 4-HO-MiPT and MET.
4-Hydroxy-N-methyl-N-ethyltryptamine also known as 4-HO-MET, Methylcybin, Metocin, and “Colour” is a novel psychedelic substance of the tryptamine class that produces psilocybin-like psychedelic effects when administered. It is structurally related to psychedelic tryptamines like 4-AcO-DMT, 4-HO-MiPT and MET. It is generally described as a more recreational version of psilocybin mushrooms (“magic mushrooms”) due to its less serious headspace and leaning towards visual effects.
4-HO-MET was first synthesized by Alexander Shulgin and documented in his book TiHKAL (“Tryptamines I Have Known and Loved”). Similar to psilocin, the active dosage is listed as 10-20 mɡ. However, since the publication of TiHKAL, a large body of anecdotal reports suggests that the active dose can vary greatly. Some users report very heavy experiences with doses as low as 17mg, while others report light experiences with doses as high as 30 mg.Possible causes for this observed effect may be attributed to individual differences in neurochemistry and metabolism as well as large variations in the quality of different batches and physical forms (e.g. the HCl vs. fumarate salt) that it has appeared in.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. As with psilocin, there have been no reports of deaths from 4-HO-MET despite the existence of reports of people taking doses up to 150 mg, which far exceeds the active dose. This suggests that it is well-tolerated physiologically.
Today, 4-HO-MET is either used recreationally or as an entheogen and is typically distributed as a grey-area research chemical by online vendors.
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