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3-Methoxyphencyclidine (commonly known as 3-MeO-PCP or 3-MeO) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic, and hallucinogenic effects when administered. It is structurally related to arylcyclohexylamines like PCP, MXE, and 3-MeO-PCE.
3-MeO-PCP was first synthesized in 1979 to investigate the structure-activity relationship of phencyclidine (PCP) derivatives. Its activity in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle reported qualitative similarities to PCP along with comparable potency.
Like other substances of its class, particularly methoxetamine (MXE), phencyclidine (PCP), and 3-MeO-PCE, it is known to primarily induce a state referred to as “dissociative anesthesia”, although the extent to which this occurs is reported to be highly dose-dependent and variable in its effects. It is commonly taken orally and nasally, although it may also be smoked and injected. It has been noted for its subtle come up and tendency to produce delusions of sobriety, which can lead to compulsive redosing.
Today, 3-MeO-PCP is rarely sold on the streets and almost exclusively obtained as a gray area research chemical through the use of online vendors, where it is commonly used as a recreational substance and, more rarely and controversially, as an entheogen. Due to its potent dissociative, stimulant and hallucinogenic effects, commonly reported habit-forming properties, as well as unknown toxicity profile, it is strongly recommended that one use proper harm reduction practices if using this substance.
3-Methoxyphencyclidine, or 3-MeO-PCP, is a synthetic dissociative of the arylcyclohexylamine class. 3-MeO-PCP contains cyclohexane, a six-member saturated ring, bonded to two additional rings at R1. One of these rings is a piperidine ring, a nitrogenous six member ring, bonded at its nitrogen group. The other ring is an aromatic phenyl ring, substituted at R3 with a methoxy group.
3-MeO-PCP is a PCP derivative and structurally analogous to 4-MeO-PCP.
3-MeO-PCP acts as an NMDA receptor antagonist. A specific subtype of glutamate receptor, NMDA (N-Methyl-D-Aspartate), modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open.
Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity leads to loss of normal cognitive and affective processing, psychomotor functioning, anesthesia and eventually an almost identical equivalent of the famous “k-hole.”
3-MeO-PCP has a Ki of 20 nM for the NMDA receptor, 216 nM for the serotonin transporter (SERT) and 42 nM for the sigma-1 receptor. It binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions, followed by 2-MeO-PCP and 4-MeO-PCP.
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