2′-Oxo-PCE (also known as as Eticyclidone, and O-PCE) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic, stimulating and hallucinogenic effects when administered. It is structurally related to arylcyclohexylamines like MXE, 3-MeO-PCE, and deschloroketamine and is speculated to produce its effects through its activity as an NMDA receptor antagonist.
The structural similarities O-PCE shares with DCK, which has been speculated to have antibacterial properties,has raised some concern as to whether it also shares these properties as well. However, due to the lack of scientific research on the subject, whether this is true currently remains entirely unknown. It is advised that users this substance should keep in mind that the possibility of prolonged use may pose a serious threat to one’s health and immune system if this does prove to be the case.
O-PCE is an example of a contemporary designer drug specifically chosen to mimic and/or replace the functional and structural features of its predecessors. It has recently become commonly available through online research chemical vendors where it is being marketed and sold as a designer drug replacement for MXE and other dissociatives for recreational purposes. Unlike many other research chemical dissociatives, there is almost a total absence of scientific literature on O-PCE, particularly with regards to its toxicity, addiction and abuse potential in humans.
Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. It is strongly recommended that one use harm reduction practices if choosing to use this substance.
O-PCE, or 2′-Oxo-PCE, belongs to the arylcyclohexylamine chemical class. Arylcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. Deschloroketamine contains a phenyl ring bonded to a cyclohexane ring substituted with an oxo group (cyclohexanone) at R1. Bound to the adjacent alpha carbon (R2) of the cyclohexanone ring is an amino ethyl chain -NCH2CH3. 2′-Oxo-PCE, like MXE contains an amino ethyl chain rather than the amino methyl chain found in DCK and ketamine. 2′-Oxo-PCE is homologous to DCK, differing only in the length of their carbon chain.
2′-Oxo-PCE (Eticyclidone, O-PCE) is an example of a contemporary designer drug specifically chosen to mimic and/or replace the functional and structural features of its predecessors. 2′-Oxo-PCE (Eticyclidone, O-PCE) is being marketed and sold as a designer drug replacement for MXE and other dissociatives for recreational purposes.
In comparison to DCK, Ketamine and MXE, 2-Oxo-PCE can be described as generally more stimulating with fewer cognitive and sensory suppressions. The first half of its duration presents primarily stimulating effects with minimal dissociation whilst the second half is primarily dissociating with minimal stimulation.